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kappa-chain gene
Pharmaсol, 03.02.2005 00:20
Объясните пожалуйста, что такое kappa-chain gene
gostya, 03.02.2005 01:46
Esli pro antibodies, to vot:
The V-J joining process involved in making a human k light chain. In the "germ-line" DNA (where the antibody genes are not being expressed and are therefore not rearranged), the cluster of five J gene segments is separated from the C-region exon by a short intron and from the 40 V gene segments by thousands of nucleotide pairs. During the development of a B cell, the randomly chosen V gene segment (V3 in this case) is moved to lie precisely next to one of the J gene segments (J3 in this case). The "extra" J gene segments (J4 and J5) and the intron sequence are transcribed (along with the joined V3 and J3 gene segments and the C-region exon) and then removed by RNA splicing to generate mRNA molecules in which the V3, J3, and C sequences are contiguous. These mRNAs are then translated into k light chains. A J gene segment encodes the C-terminal 15 or so amino acids of the V region, and the V-J segment junction coincides with the third hypervariable region of the light chain, which is the most variable part of the V region.
The V-J joining process involved in making a human k light chain. In the "germ-line" DNA (where the antibody genes are not being expressed and are therefore not rearranged), the cluster of five J gene segments is separated from the C-region exon by a short intron and from the 40 V gene segments by thousands of nucleotide pairs. During the development of a B cell, the randomly chosen V gene segment (V3 in this case) is moved to lie precisely next to one of the J gene segments (J3 in this case). The "extra" J gene segments (J4 and J5) and the intron sequence are transcribed (along with the joined V3 and J3 gene segments and the C-region exon) and then removed by RNA splicing to generate mRNA molecules in which the V3, J3, and C sequences are contiguous. These mRNAs are then translated into k light chains. A J gene segment encodes the C-terminal 15 or so amino acids of the V region, and the V-J segment junction coincides with the third hypervariable region of the light chain, which is the most variable part of the V region.
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watches89, 04.12.2023 07:24
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vrida2, 02.02.2024 21:49
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