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: Leukemia.png , . , .

- (cancer-propagating cells (CPCs)) . CPCs. , CPCs, . (hematopoietic stem cell (HSC)). , HSC, - (leukemia-propagating cells (LPCs)). , . . , , .

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, , ALL, 7 . 5 . , . , LPCs. , , LPCs, ALL.

50 ALL , , 30 , 15 , 5 . 15 20 . 5 20 , , . 30 , . GDF15 BCL-2. , .


: Duan CW, Shi J, Chen J, Wang B, Yu YH, Qin X, Zhou XC, Cai YJ, Li ZQ, Zhang F, Yin MZ, Tao Y, Mi JQ, Li LH, Enver T, Chen GQ, Hong DL. Leukemia propagating cells rebuild an evolving niche in response to therapy. // Cancer Cell. 2014; V. 25: P. 778-793.

: .
SV , LPCs - leukemia-propagating cells, MSCs .
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GDF15, , ALL , . GDF15, ALL , Smad3, TGF-β.
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