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ìèêðîðíê ðåãóëèðóþò ïëàñòè÷íîñòü íåéðîíîâ ìîçãà

Dr. Hogart, 20.01.2006 23:22
ìèêðîÐÍÊ - ýòî áîëüøîé êëàññ êîðîòêèõ íåêîäèðóþùèõ ÐÍÊ, ðåãóëèðóþùèõ ñàìûå ðàçíûå ïðîöåññû - îò êëåòî÷íîãî öèêëà äî ðàçâèòèÿ îðãàíèçìà è ãåìîïîýçà. Ðåãóëÿöèÿ, ÿâëÿþùàÿñÿ êàê ïðàâèëî âðåìå- è òêàíåñïåöèôè÷íî, îñóùåñòâëÿåòñÿ çà ñ÷åò ïîäàâëåíèÿ òðàíñëÿöèè ìÐÍÊ, ñîäåðæàùåé ó÷àñòîê êîìïëåìåíòàðíîñòè ê äàííîé ìèêðîÐÍÊ. Èññëåäîâàíèå, ïðîâåäåííîå â Children's Hospital Boston (Nature) ïîêàçàëî, ÷òî îäíà èç ìèêðîÐÍÊ, miR134, íåîáõîäèìà äëÿ ðåãóëÿöèè ôóíêöèîíèðîâàíèÿ ìîçãà. Ïðè èíãèáèðîâàíèè àêòèâíîñòè ýòîé ìèêðîÐÍÊ øèïèêè íà ñèíàïñàõ íåéðîíîâ ìîçãà óäëèíÿëèñü è óòîëùàëèñü. Îêàçàëîñü, ÷òî miR134 ïîäàâëÿåò òðàíñëÿöèþ ìÐÍÊ ãåíà Limk1, êîòîðûé êàê ðàç è íóæåí äëÿ ðîñòà øèïèêîâ. Àâòîðû ðàáîòû ñïåêóëèðóþò, ÷òî äàííàÿ ìèêðîÐÍÊ ìîæåò èãðàòü ðîëü â òî÷íîé íàñòðîéêå ïîçíàâàòåëüíûõ ôóíêöèé îðãàíèçìà çà ñ÷åò ñåëåêòèâíîé ðåãóëÿöèè ðàçâèòèÿ òåõ èëè èíûõ ñèíàïñîâ â îòâåò íà ñòèìóëû èç îêðóæàþùåé ñðåäû. Ïî ñîîáùåíèþ ñ www.biologynews.net
vrida2, 06.06.2020 15:16
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